Humans can withstand varying air and water pressures, but breathing becomes difficult at depths beyond a few feet without pressurized air, like that provided by scuba tanks. The lungs can only generate a pressure differential of about 20-30 inches of water column, which limits the depth at which a person can effectively inhale. With pressure-regulated devices, the body can endure significant hydrostatic pressures, but extreme depths pose risks. At certain depths, the pressure can exceed the structural limits of oxygen tanks, raising concerns about the effects on the human body, including the ribcage and internal organs. Ultimately, the first factor leading to death in extreme conditions is likely the inability to breathe due to pressure-induced lung compression or failure of the respiratory system.