Internal combustion engines can run on hydrogen by utilizing the chemical reaction where hydrogen combusts to form water (H2O). The process involves combustion heat, which converts the hydrogen gas into a high-pressure state, allowing for engine expansion. This expansion generates work, as described by the equation Q=m Cp del T + del (PV). The work done by the engine can be expressed through the integral W= Int (V_int to V_final) P dV, illustrating how pressure-volume changes contribute to engine efficiency. Understanding these principles is crucial for optimizing hydrogen as a fuel source in internal combustion engines.