Importance of Y-chromosome in avoiding bladder cancer?

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As males age, they experience a loss of Y chromosomes due to rapid cell turnover, which has significant implications for cancer risk, particularly bladder cancer. A study led by Dan Theodorescu at Cedars-Sinai Cancer, published in Nature, establishes a link between Y chromosome loss and the immune system's ability to combat cancer. The research indicates that this loss allows bladder cancer cells to evade immune detection and proliferate aggressively, increasing the disease's severity and treatment challenges. The findings underscore the importance of early detection and preventive measures for bladder cancer in older males, as well as the need for further investigation into the Y chromosome's role in other cancers and overall health. This research highlights the Y chromosome's dual role in defining male characteristics and enhancing cancer immunity, urging men to be vigilant about their health as they age.
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Males lose sex chromosome as they age. It could make cancer more deadly, study says​

https://www.yahoo.com/news/males-lose-sex-chromosome-age-211624452.html

Dan Theodorescu, director of Cedars-Sinai Cancer and corresponding author of the study, and a team of leading researchers from across the country published their findings in Nature on June 21.

As males age, they begin to lose some of their Y chromosomes due to rapid cell turnover, the study said.

“This study for the first time makes a connection that has never been made before between loss of the Y chromosome and the immune system’s response to cancer,” Theodorescu said in a June 21 release. “We discovered that loss of the Y chromosome allows bladder cancer cells to elude the immune system and grow very aggressively.”

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The findings of this study are extremely significant in understanding the importance of the Y-chromosome in avoiding bladder cancer. The Y-chromosome is responsible for determining male sex characteristics and is also involved in regulating the immune system. As males age and lose their Y-chromosomes, it weakens their immune response, making them more susceptible to cancer.

This study sheds light on the connection between the loss of Y-chromosome and the immune system's response to cancer, specifically bladder cancer. By eluding the immune system, cancer cells are able to grow more aggressively, making it more difficult to treat and potentially more deadly.

These findings emphasize the importance of early detection and prevention of bladder cancer, especially in older males who are more likely to have lost their Y-chromosomes. It also highlights the need for further research on the role of the Y-chromosome in other types of cancer and how it may impact treatment and outcomes.

Overall, this study highlights the significance of the Y-chromosome in not only determining sex characteristics but also in protecting against certain types of cancer. It is a reminder to all males to take care of their health and to be aware of any changes in their bodies as they age.
 
I've been reading a bunch of articles in this month's Scientific American on Alzheimer's and ran across this article in a web feed that I subscribe to. The SA articles that I've read so far have touched on issues with the blood-brain barrier but this appears to be a novel approach to the problem - fix the exit ramp and the brain clears out the plaques. https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours The original paper: Rapid amyloid-β...

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