Iron and Vitamin C: Enhancing Absorption

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Discussion Overview

The discussion revolves around the potential for vitamin C to enhance the absorption of iron, specifically in the context of dermal application using iron oxide nanoparticles in cosmetics. Participants explore the differences between oral and topical absorption and the implications for skin care products.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • Some participants suggest that oral vitamin C aids in iron absorption in the gut, but question whether it has the same effect when applied topically with penetration enhancers.
  • One participant argues that dermal absorption is fundamentally different from gut absorption, indicating that vitamin C's role in enhancing iron absorption may not apply to skin applications.
  • Concerns are raised about the necessity of increasing iron intake, with a suggestion that most individuals likely receive sufficient iron through their diet unless they have specific malabsorptive disorders.
  • Another participant notes the historical use of mineral particulates on the skin and mentions the modern trend of adding vitamins to skin preparations, including vitamin C.
  • There is a mention of various cosmetic products, such as Bare Minerals, which incorporate fine mineral particulates and vitamins, though the effectiveness of these combinations remains uncertain.
  • Some participants express a preference for simpler formulations without nanoparticles until more research is available.

Areas of Agreement / Disagreement

Participants express differing views on the effectiveness of vitamin C in enhancing dermal iron absorption, with no consensus reached on the topic. Concerns about dietary iron sufficiency and the safety of using vitamin C in skin creams are also debated.

Contextual Notes

The discussion highlights the lack of research specifically addressing the dermal absorption of iron in conjunction with vitamin C, indicating a gap in knowledge that may affect participants' opinions.

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I might be posting this in the wrong area. If so, sorry about that. :<)

From what little I understand of the subject oral vitamin C helps the body absorb iron. Should this be the case, could topical vitamin C in combination with penetration enhancers also enhance dermal absorption of iron oxide?
 
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Here is an abstract of a paper about iron absorption and ascorbic acid (Vit C) in the human gut - field trials.
http://www.ajcn.org/cgi/content/abstract/67/5/873

My view on your question is no. Dermal absorption depends on the moleule or a nanoparticle in question being able to pass through membranes. Vitamin C in the gut has a very different effect on absorption of minerals in the gut than it would have dermally.
I don't know of any research on the subject, so this is a guess.

From:
http://www.atsdr.cdc.gov/hac/pha/georgetown/gsc_p1.html
The only standards available to use for comparison are those that have been developed for use in occupational settings. Occupational settings typically involve much higher exposures and exposure to many materials. The American Conference of Government Industrial Hygienists (ACGIH) recommend an exposure limit of 5,000 µg/m3 time weighted average measured as iron. The United States Occupational Safety and Health Administration (OSHA) limits permissible exposure to 10,000 µg/m3 measured as total iron particulates.

Particulate matter is a complex ...

Why are you interested? If you are considering increasing the iron available to your body as a nutrient - don't. Unless you have malabsorptive disorders, you are probably already getting more iron in your diet than you need. If you are working around iron particulates, don't use vitamin C skin cream if you think it has an effect.
 
Last edited:
jim mcnamara said:
Why are you interested? If you are considering increasing the iron available to your body as a nutrient - don't. Unless you have malabsorptive disorders, you are probably already getting more iron in your diet than you need. If you are working around iron particulates, don't use vitamin C skin cream if you think it has an effect.

Thanks, Jim.

I was more concerned with dermal absorption. A number of cosmetics and skin preparations contain nano-particles of coated or uncoated iron oxide with various penetration enhancers and vitamins, C being a typical additive. Due to the reduced particle size the question came to mind.
 
Bare Minerals makeup

People have been putting fine mineral particulates on their skin for a lot of reasons for a very long time. There is even archeological data to believe other human species may have used used ochre on the skin.

The addition of other goodies, ascorbic acid and tocopherols, is new to the skin preparation market. I'd vote for something like Bare Minerals if I needed makeup. But since they do not let me out, it doesn't matter.
 
jim mcnamara said:
Bare Minerals makeup

People have been putting fine mineral particulates on their skin for a lot of reasons for a very long time. There is even archeological data to believe other human species may have used used ochre on the skin.

The addition of other goodies, ascorbic acid and tocopherols, is new to the skin preparation market. I'd vote for something like Bare Minerals if I needed makeup. But since they do not let me out, it doesn't matter.

I'm sure you'd look smashing in the misty mauve eyeshadow I saw earlier. *<) Seriously, quite a few men have been using mineral makeup as a light sunscreen and to add a little color in winter.

A few mineral makeup companies choose not to use nano-particles so there are choices out there. Until more studies are done I think I'd rather err on the side of something simple and effective without the bells and whistles.
 

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