In a multi-charge electric field, the potential at a specific point can theoretically be zero, but it is typically defined in relation to a reference point, often taken as infinity. The potential difference is what can be calculated, not the absolute potential at a single point. Since potential at infinity is considered zero, all other potentials are measured against that reference. Therefore, while potential can be zero at infinity, it is not applicable within the field itself. The discussion emphasizes the importance of understanding potential difference rather than absolute potential values.