Is large-scale genetic manipulation of bacteria feasible?

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Recent research highlights significant advancements in large-scale genetic manipulation, particularly in bacterial genomes. Scientists at the J Craig Venter Institute are pioneering techniques for synthesizing entire genomes from scratch and inserting them into bacteria with removed DNA, effectively creating "synthetic life." This approach was detailed in the 2010 study by Gibson et al., which demonstrated the creation of a bacterial cell controlled by a chemically synthesized genome. Additionally, George Church and his team have introduced a method that involves making targeted mutations across various bacterial strains and then combining these mutations to form a single, re-engineered bacterial genome, as outlined in their 2011 study by Isaacs et al. These developments mark significant progress in the field of synthetic biology and genetic engineering.
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Does research exist about methods or the possibility of large scale genetic manipulation?
 
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Recent research has been focused on methods for the large-scale re-engineering of bacterial genomes. Scientists at the J Craig Venter Institute are developing the means for synthesizing genomes from scratch and inserting these genomes into bacteria whose DNA has been removed in order to create "synthetic life." (see Gibson et al. 2010. Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome. Science 329:52. doi:10.1126/science.1190719). George Church and colleagues have developed an alternative approach that involves making small sets of mutations in a different number of bacterial strains, then stitching together these mutations into a single re-engineered bacterial genome (see Isaacs et al. 2011 Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement. Science 333:348. http://dx.doi.org/10.1126/science.1205822).
 

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