From the perspective of how life got started on earth, it seems dauntingly unlikely that information-carrying molecules and reaction-catalyzing molecules would emerge at the same time and place. That impasse seemed to have been bridged with the discovery in 1982 that certain kinds of RNA have catalytic properties. It followed that a single RNA molecule could both carry information and catalyze reactions.
The concept of the RNA world, a phrase coined by Walter Gilbert of Harvard, held that in the beginning there were no proteins and no DNA, just RNA molecules that built more RNA molecules from chemical subunits known as nucleotides.
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Both Dr. Cech and Dr. Orgel, a leading authority on the origin of life, suggest that there was a pre-RNA world, in which the staring role was played by some other self-replicating, catalytic molecule.
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The earliest known fossils exist in rocks that are 3.85 billion years old, leaving a mere 150 million years for life to have started.