Probably the most important issue not discussed so far in this review is the question of whether the reality of the quantum state can be established experimentally...In modern parlance, tests of Bell's Theorem are device independent. In contrast, a test of the reality of the quantum state would not be device independent simply because the "quantum state" is the thing we are testing the reality of, and that is a theory dependent notion. Consequently, one has to assume that our quantum theoretical description of the way that our preparation devices work is more or less accurate, in the sense that they are approximately preparing the quantum states the theory says they are, in order to test the existing ψ-ontology results. Therefore, it is desirable to have a more theory independent notion of whether a given set of observed statistics imply that the "probabilistic state", i.e. some theory-independent generalization of the quantum state, must be real. It is not obvious whether this can be done, but if it can then experimental tests of ψ-ontology results would become much more interesting.
Of course, one can still perform non device independent experimental tests. This amounts to trying to prepare the states, perform the transformations, and make the measurements involved in a ψ-ontology result and checking that the quantum predictions are approximately upheld. Due to experimental error, the agreement will never be exact, but one can bound the overlap between probability measures representing quantum states instead of showing that it must be exactly zero. For the special case of the PBR Theorem given in Example 7.9, this has been done using two ions in an ion trap. However, the experimental result only shows that the overlap in probability measures must be smaller than the quantum probability, and not that it must be close to zero. This is quite far from establishing the reality of the quantum state, since for that one would want to test many pairs of quantum states with a variety of different inner products, and the PBR measurement for states with large inner product requires an entangled measurement on a large number of quantum systems. This is not likely to be feasible until we have a general purpose quantum computer.