Jumping up and down does not significantly disrupt cellular structures or DNA within the body. The DNA is embedded in the cytoplasm, which maintains stable conditions through a semipermeable membrane. Any violent shaking would cause severe damage to larger organ systems long before affecting DNA. Cells possess complex mechanics involving the cytoskeleton and membrane interactions, which help distribute stresses and strains. The movement of macromolecular complexes, like DNA, in water is limited, primarily relying on diffusion and interactions with proteins. When the body moves, internal components move cohesively rather than independently, and the strength of chemical bonds ensures that DNA remains intact despite physical activity.