Memory B and T Cells: How Many and How Long?

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Memory B and T cells play a crucial role in the immune response to specific antigens. While exact numbers of these cells for a specific antigen can vary, studies indicate that memory B cells can persist for decades. For instance, research on smallpox vaccination shows that memory B cells can last over 50 years, maintaining a stable frequency of about 0.1% of total circulating IgG+ B cells. These cells can effectively respond to re-exposure to the antigen, demonstrating their functional longevity. Additionally, the need for tetanus boosters every 10 years suggests that while some memory cells may have shorter lifespans, others can endure significantly longer, contributing to long-term immunity.
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I've learned about memory B and T cells. I'm wondering how many of each a person has for a specific antigen? How long do they live?
 
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I don't know the exact numbers, but when you look at tetanus vaccinations you need to get a booster after 10 years. So they can live up to ten years.

Here a study who looked at it in detail: http://www.jimmunol.org/cgi/content/full/171/10/4969#F1
In this study, we demonstrate that smallpox vaccine-specific memory B cells last for >50 years in immunized individuals. Virus-specific memory B cells initially declined postimmunization, but then reached a plateau 10-fold lower than peak and were stably maintained for >50 years after vaccination at a frequency of 0.1% of total circulating IgG+ B cells. These persisting memory B cells were functional and able to mount a robust anamnestic Ab response upon revaccination.
 

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