Knocking out SCH9 and SIR2 in mice has been suggested to potentially increase their lifespans by up to six times, similar to findings in yeast. Longo's research indicates that age-dependent mutations occur at a significantly slower rate in organisms lacking these genes, raising questions about whether this effect is applicable to mice. Concerns arise regarding the potential downsides of extended lifespan, such as the risk of excessive cell proliferation leading to health issues. Additionally, advancements in extending the lifespan of human cells, including liver cells, suggest that these findings may not be limited to simpler organisms, indicating broader implications for longevity research.
