The stability of ortho, meta, and para isomers of benzene depends on the substituents attached to the benzene ring. In the case of ortho-di-chlorobenzene, meta, and para isomers can be compared for stability based on steric hindrance and electronic effects. Larger substituents, like bromine, create more steric strain when positioned close together, making the ortho isomer less stable. The para isomer generally exhibits the highest stability due to minimized steric interactions and optimal distance between substituents. Understanding these factors is crucial for determining the most stable isomer in substituted benzene compounds.