Optogenetics and neurons firing

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SUMMARY

Optogenetics integrates deep brain stimulation, fiber optics, and gene therapy to enable real-time monitoring and manipulation of neuronal activity. Researchers have successfully injected mice neurons with a gene that causes them to emit green fluorescence upon firing, allowing simultaneous stimulation and observation through the same fiber-optic cable. This two-way communication capability enhances the understanding of neural dynamics, including regular spiking, phasic bursting, and fast spiking. The application of plant genes in mammalian neurons exemplifies the innovative approaches in neuroscience research.

PREREQUISITES
  • Understanding of optogenetics principles
  • Familiarity with fiber optic technology
  • Knowledge of gene therapy techniques
  • Basic concepts of neuronal firing patterns
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  • Research advancements in optogenetic tools and techniques
  • Explore the role of fiber optics in neural monitoring
  • Study the implications of gene therapy in neuroscience
  • Investigate neuronal firing patterns and their significance
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Neuroscientists, biomedical researchers, and anyone interested in the intersection of genetics and neural engineering will benefit from this discussion.

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Optogenetics is the combination of deep brain stimulation with fiber optics and gene therapy.

I have read that there can be two way traffic (http://www.wired.com/magazine/2009/10/mf_optigenetics/all/1")

By injecting mice neurons with yet another gene, one that makes cells glow green when they fire, researchers are monitoring neural activity through the same fiber-optic cable that delivers the light. The cable becomes a lens. It makes it possible to “write” to an area of the brain and “read” from it at the same time: two-way traffic.

I know that there are no big or small firing of neurons - all firings are the same size. I was wondering if the fiber-optic cable can detect the difference between regular spiking, phasic bursting or fast spiking.
 
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Has there been any progress with optogenetics? It really does sound quite fascinating and could really help doctors and researchers understand the human brain and how it functions. It's quite fascinating how they can take a plant gene and implant it into a mammals neurons and brain.
 

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