Designing a portable device powered by two AA batteries requires a solution for generating both positive and negative 5V. The nominal 3V output from two AA batteries can be insufficient, leading to suggestions such as using voltage dividers from a higher voltage source or employing multiple voltage regulators to achieve the desired outputs. A more efficient approach involves using a DC-DC converter for +5V and another for -5V, or a single 10V output converter with a virtual ground. Resources like Tangentsoft provide valuable insights, especially for audio applications, and can guide in selecting appropriate components. Overall, careful consideration of voltage regulation and balance is crucial for optimal performance in audio devices.