Possible to find amount of a substance in tissue sample?

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Quantifying a specific substance, such as a polymer hydrogel of poly[N-(2-hydroxypropyl) methacrylamide], in tissue samples is feasible through various analytical chemistry methods. Techniques such as spectroscopy, chromatography, and mass spectrometry can be employed to determine the concentration of the substance in a sample or to compare its relative amounts across multiple samples. For detailed methodologies and specific protocols, consulting existing literature in analytical chemistry is recommended.
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If one has a tissue sample that contains a known substance (specifically a polymer hydrogel of poly[N-(2-hydroxypropyl) methacrylamide), is there a way to quantify the amount of that substance in the sample, or a way to compare the relative amount of the substance in multiple tissue samples?
 
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Whole analytical chemistry deals with methods designed to solve this type of the question. I suppose the answer is yes - but for details you will need to consult literature.
 

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