To differentiate the function (2x+3)^3(x-4), the product rule is applied, defined as y'(x) = f'(x)g(x) + f(x)g'(x). The first function, f(x), is (2x+3)^3, and its derivative f'(x) is calculated using the power rule, resulting in f'(x) = 3(2x+3)^2(2). The second function, g(x), is (x-4), with its derivative g'(x) equal to 1. The final derivative is obtained by combining these results correctly. Careful application of these rules is essential for accurate differentiation.