Hi delc1,
First I played with the sum of $4x$ and $10y$ and applied the AM-GM and I ended up with $\dfrac{4x+10y}{2}\ge (4x\cdot10y)^{\dfrac{1}{2}}_{\phantom{i}}$. This gave us the idea that if we wanted the power of 3 on one side of the inequaliy sign, we must apply the AM-GM inequality to a total of 3 terms.
Note that $1080=2^33^35$ and that the RHS of the inequality$(4x+10y)^3\ge1080x^2y$ consists of two $x$ and and one $y$, I know I must separate the $4x$ into the sum of $2x+2x$ and by applying the AM-GM to the terms $2x,\,2x,\,10y$, I get:
$\dfrac{2x+2x+10y}{3}\ge (2x\cdot2x\cdot10y)^{\dfrac{1}{3}}_{\phantom{i}}$, or equivalently,
$(4x+10y)^3\ge1080x^2y$