A discussion arose about whether reputable science journals like Science or Nature publish studies with null results or heavily replicated studies. Participants acknowledged that publication bias is a significant issue in science, driven by the need for journals to attract readers. There was a consensus that while it would be beneficial to publish negative results, it is often not good business practice for journals. The conversation included a suggestion to contact these journals directly if there are specific concerns. Overall, the thread highlighted the tension between scientific integrity and the commercial aspects of publishing.