Reactivity of Ketones: Do They React with Thio Alcohols?

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Ketones react with thio alcohols, producing thioketals under acidic conditions. While ketones do not react with monohydric alcohols, they can form ketals when reacted with alcohols. A common protecting group for ketones is 1,3-dithiopropane, which forms a stable cyclic thioketal. This cyclic thioketal is resistant to base and can be easily removed by acid. Understanding these reactions is crucial for effective carbonyl protection strategies in organic chemistry.
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Do ketones react with thio alcohols?

I was studying the protection of carbonyls through acetals, and in my notes, I'd written down that ketones don't react with monohydric alcohols. Do they react with thio alcohols?
 
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Ketones do indeed react with alcohols. The product is a ketal under acidic conditions. Thiols react as well to produce thioketals. One protection group for ketones is 1,3-dithiopropane. The cyclic thioketal is the protected group stable to base and easily removed by acid.
 

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