Reformulating an integral as an ODE problem involves differentiating both sides of the equation, but challenges arise when the integral has specific limits. The integral M(y) = ∫(a to b) m(x, y) dx yields a function of y, yet turning it into an ODE requires careful consideration of the relationship between y and x. The discussion highlights the confusion surrounding whether y is a function of x, especially given that the integral produces a numerical result rather than a function. Users express frustration over using MATLAB's ode45, noting that it integrates over a range rather than providing an equivalent to the integral directly. Ultimately, the goal is to ensure that both methods yield the same result, but discrepancies in initial values and function definitions complicate this process.