Sedentary behavior & reduced medial temporal lobe thickness

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The discussion centers on concerns about the validity of a study linking excessive sitting to memory improvement, as presented in a PLOS ONE article. The original poster expresses skepticism about the statistical analysis, particularly regarding the scatter diagrams and the influence of outliers on the data. Key points of inquiry include the meaning of the β value in the statistical results and the interpretation of confidence intervals and p-values. The poster seeks clarification on whether the data supports the claim that reducing sitting time enhances memory, questioning the reliability of the p-value as an indicator against the null hypothesis. The conversation emphasizes the need for a deeper understanding of the statistical methods used in the study to assess its conclusions effectively.
Buzz Bloom
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My wife keeps telling me that I need to avoid sitting at the computer so much. She sent me the following link.
I confess that I don't find the data presented in the article very convincing, and I would appreciate comments regarding the statistical analysis from knowledgeable participants.

As I see it, the data consists of two scatter diagrams (Figs. 1 and 2) and two data summaries (Tables 1 and 2). Table 1 describes the characteristics of the population, and Table 2 (shown below) gives the statistical results. As I look at the scatter diagrams, the steepness of the least mean square fit seems to me to be strongly influenced by a few data points I would call outliers. The data in Table 2 gives values for β and p-value. I do not understand what β represents, but the range of 95% CI seems seems odd that it is so much larger than the value of β.

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Ygggdrasil said:
They probably performed some sort of logistic regression on the data
Hi Ygggdrasil:

You are probably right about that, but I would like to understand, if I can, whether the data in the Table 2 reliably implies that there is good support for the premise that avoiding excessive sitting improves memory. In particular:
(1) Do you know what β represents?
(2) For example looking at the first row, do the numbers {-0.02, (-0.04,-0.002)} mean that:
(a) β=-0.02 is the mean or median of a probability distribution of possible values,
(b) the probability that the true value of β ε {-0.04,-0.02} is approximately 0.475, and
(c) the probability that the true value of β ε {-0.02,-0.002} is approximately 0.475?​
(3) Is the p-value of 0.03 a reliable predictor of the premise, or it it only an indication (weak?) that the data is not consistence with the null hypothesis? Am I correct that this support against the null hypothesis implies only that the two correlated variables were not likely to have been generated by random numbers from a single distribution? Or is there some stronger implication?

I would appreciate any comments you would care to make.

Regards,
Buzz
 
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