Sleep loss may cause brain damage

AI Thread Summary
Recent research highlights the potential for brain damage due to sleep loss, particularly among shift workers and truck drivers. Neuroscientist Sigrid Veasey from the University of Pennsylvania emphasizes that the common belief in "paying back" sleep debt through extended naps is misleading. Long-term sleep deprivation can lead to irreversible brain power loss, even after attempts to recover sleep. The study, published in the Journal of Neuroscience, suggests that chronic sleep deprivation may indicate lasting brain injury. Additionally, the discussion raises concerns about how to mitigate these effects, questioning the efficacy of short naps and the need for longer sleep periods for proper brain maintenance. Some companies are already recognizing the dangers of sleep deprivation, implementing policies like shift rotation and limiting work hours, which could influence future labor laws if validated in human studies. Furthermore, sleep deprivation has been linked to the accumulation of metabolic waste in the brain, underscoring the critical importance of adequate sleep for cognitive health.
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Shift workers beware: Sleep loss may cause brain damage, new research says
http://www.cnn.com/2014/03/19/health/sleep-loss-brain-damage/index.html?hpt=hp_t2

Are you a truck driver or shift worker planning to catch up on some sleep this weekend?
Cramming in extra hours of shut-eye may not make up for those lost pulling all-nighters, new research indicates.
The damage may already be done -- brain damage, that is, said neuroscientist Sigrid Veasey from the University of Pennsylvania.
Alzheimer's & Sleep
The widely held idea that you can pay back a sizeable "sleep debt" with long naps later on seems to be a myth, she said in a study published this week in the Journal of Neuroscience.
Long-term sleep deprivation saps the brain of power even after days of recovery sleep, Veasey said. And that could be a sign of lasting brain injury.
 
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Not surprising to me. I subscribe to the restorative theory of sleep.

http://www.nature.com/nrn/journal/v14/n6/images/nrn3494-f2.jpg
 
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Indeed not that surprising: even fruit flies suffer from sleep deprivation. Great research though, the big question is now: how can damage be prevented? Could short naps be sufficient to counter negative effects?
 
Monique said:
Indeed not that surprising: even fruit flies suffer from sleep deprivation. Great research though, the big question is now: how can damage be prevented? Could short naps be sufficient to counter negative effects?

Longer term overnight trafficking processes suggest to me that there would be some maintenance processes that require a sufficient amount of time. Whether or not they're important to prevention of tissue damage I'm not sure:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564590/figure/F8/
 
Interesting, some companies it seems to me intuitively know that sleep deprivation is harmful to workers and thus considered it in their policy like shift rotation, maximum 12- hour duty and multiple/flexible day-offs. If proven on human specimen, perhaps such aforementioned company policy will be enacted into labor laws? Maybe not.

Sleep deprivation also causes accumulation of metabolic waste in the brain of mice specimen... http://www.kurzweilai.net/how-the-brain-takes-out-the-trash-while-we-sleep/comment-page-1
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) he structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom
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