To find the area defined by the vertices (3,9,8), (0,5,1), (-1,-3,-3), and (2,1,4), the points are confirmed to be coplanar, leading to ambiguity in determining the area. The discussion highlights that without a clear method to connect the points, multiple configurations can yield different areas. If the points form a convex quadrilateral, the area can be calculated by summing the areas of triangles formed by the vertices. Alternatively, if one point is inside the others, the area can be derived from the triangles that include the inner point. Ultimately, more information or specific rules for connecting the points is necessary to accurately calculate the area.