To calculate the equation of a quadratic curve, use the general form y=ax^2+bx+c, where a is not zero. The vertex form y=a(x-k)^2+q provides the vertex of the parabola directly. A minimum of three points is needed to determine the quadratic equation, as each point will yield a linear equation when substituted into the general form. By solving the resulting system of equations, the coefficients a, b, and c can be determined. The final equation describes a parabola, which can be oriented at various angles but will only represent a function when it has a vertical axis.