The energy released during alpha particle emission in the decay of Am-241 to He-4 and Np-237 is calculated to be 5.486 MeV, derived from the mass difference between the parent and daughter nuclei. This mass difference is 4.0081 amu, calculated from the atomic masses of Am-241 and the combined masses of He-4 and Np-237. Energy release during alpha decay is not uniform across all decay reactions; it varies based on the specific mass differences involved. The mass-energy equivalence equation, E=mc^2, is used to determine the energy released. Generally, alpha decay releases energy in the range of a few MeV.