Stem cells from infants for research

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Discussion Overview

The discussion revolves around the use of stem cells from infants for research purposes, exploring their potential applications in treatment, the challenges associated with different types of stem cells, and the implications of using cells from other individuals in medical contexts.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • Some participants question whether stem cells from infants are ever used for treatment and whether cells from other individuals can survive in a recipient's body without rejection.
  • One participant clarifies that stem cells are not taken from infants but are harvested from embryos, noting their pluripotent nature and the ethical and supply limitations associated with embryonic stem cells.
  • There is mention of adult stem cells, which are present in the body but are not pluripotent and have limitations in terms of availability and functionality.
  • Inducible pluripotent stem cells (iPSCs) are introduced as a promising area of research, with discussions on their potential and the challenges related to their production and safety.
  • A participant shares a video link and an article related to stem cells, indicating interest in supplementary resources.
  • Another participant raises a question about the role of stem cells in cardiac tissue, suggesting a specific area of inquiry within the broader topic.

Areas of Agreement / Disagreement

Participants express varying views on the use of stem cells, with some uncertainty regarding the applications of infant-derived stem cells and the viability of using cells from other individuals. The discussion includes multiple competing perspectives on the types of stem cells and their respective challenges.

Contextual Notes

Limitations include the ethical considerations surrounding the use of embryonic stem cells, the efficiency and safety concerns related to iPSC production, and the specific challenges associated with adult stem cells.

Jarfi
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So we use stem cells from infants for research, but do they never take those stem cells and use it to treat people, is it not possible to make cells from other people live in your body? would your body reject and kill those cells?
 
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Jarfi said:
So we use stem cells from infants for research, but do they never take those stem cells and use it to treat people, is it not possible to make cells from other people live in your body? would your body reject and kill those cells?
Stem cells aren't taken from infants but harvested from http://en.wikipedia.org/wiki/Human_embryogenesis. These stem cells are desirable because they are pluripotent meaning they can give rise to any cell in an adult body. Downsides are that embryonic stem cells are always going to be in short supply because to get them you have to use discarded embryos from IVF treatments, you cannot fertilise a human egg for research.

You do raise a good point about using cells already in the body. First thing to mention would be that we do have adult stem cells (adult in this context means anything after birth) which live in our bodies and naturally give rise to different cell types. The problem is adult stem cells are not pluripotent and can only give rise to a few cell types, locating a useful adult stem cell and using it is difficult but an active research goal. Secondly is a very exciting field of research into inducible pluripotent stem cells. iPSCs are normal cells that are "reprogrammed" into pluripotent stem cells. So far methods to do this are potentially dangerous because they involve inserting DNA sequences into the genomes and so could cause cancerous mutations (although in recent years advances are removing this problem
http://www.nature.com/nature/journal/v458/n7239/abs/nature07864.html). Also the methods are abysmally inefficient producing very low amounts of cells.

However the field has great potential and is advancing along many different lines, for my money far better control of cell behaviour (tissue engineering) and reliable, efficient iPSC production will near-revolutionise medicine.
 
What about stem cells in a person's cardiac tissue? http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2012/02/15/MNFG1N7GR0.DTL
 
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