Medical Understanding Donald O. Hebb's Theory of Cell Assemblies

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The discussion centers on Donald O. Hebb's theory of cell assemblies, specifically the principle that "neurons that fire together wire together." The key point is the mechanism of synaptic strengthening when two neurons fire simultaneously. The original poster seeks clarification on whether simultaneous firing occurs when one neuron directly causes another to fire, or if multiple neurons firing independently can also lead to simultaneous activation. The consensus leans towards the latter, where multiple neurons can contribute to the firing of a target neuron, enhancing synaptic strength. Additionally, the conversation touches on the concepts of cooperation and competition among neurons, suggesting that Hebb's rule can lead to more complex interactions in neural networks. The complexity of neuronal interactions is emphasized, likening the brain's functioning to an N-Body problem in physics.
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I just started reading about Donald O. Hebb and his theories about cell assemblies. I am stuck on something really simple. From what I have read, if two neurons have a synaptic connection and they fire simultaneously, then that connection will be strengthened. What I can't understand is this - if neuron A has a connection with neuron B...

Does neuron A fire and cause neuron B to fire, and then while neuron B is firing, neuron A is still firing and that makes it a simultaneous event?
A->B
Or does neuron C cause neuron A to fire while neuron D simultaneously causes neuron B to fire and that's what makes it a simultaneous event?
C->A
D->B
I hope I am making sense. Thanks for any help.
 
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nobody? well, nevermind. I think I got my answer today in class. I believe it's the latter idea.
 
your talking about Hebb's rule right?

The idea is "Neurons that fire together wire together"...however it means that if neuron A is connected to neuron B then if neuron A fires and then neuron B fires => the synaptic strength AB increases(either by myelin sheath or by # of synaptic knobs) however if the neuron B fires before neuron A(either nothing happens or the strength decreases). Note that neuron A may not be the sole cause of neuron B...for example given the letters you stated above. let's say A and C are both connected to B...A may be the weaker neuron but if it fires with C such that B receives both at the same time the AB will also increase.

Also I wouldn't neglect your 2nd example. They would resemble what NeuralNetwork literature calls Cooperation or Competition(inhibition). Hebb's rule is the simplest Rule and it might through Cellular Automaton theory create more complex rules such as the two mentioned previously.

Remember the brain is N-Body problem w.r.t. Neurons.
 
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Thanks for the help! I am glad to see you around again.
 
thank you and i hoped what i said helped. I also forgot to mention that you could have a BA synapse if you wanted to
 
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