Viral or non viral gene therapy, in brain

[bioquest]

Im not sure if anybody here can answer this, but, this is my question

What negative health effects etc can occur from viral gene therapy being used on a human brain (to add one or more extra copies of a gene)

what are the odds of those negative effects occurring in the person from viral gene therapy being used on a human brain? (To add one or more extra copies of a gene)

Would non viral gene therapy in a human brain be effective enough to add one or more extra copies of a gene?

These questions are in regards to each type etc of virus though, not just AAV.

thanks..not sure if this is the area of expertise of anyone here but anyways

 

[magnusrobot12]

one negative effect is delivery of virus to the brain that would most likely involved stereotaxic neurosurgery. another negative effect is antibodies being generated to the viral capsid proteins but i think you will probably be OK with the first administration, so as long as you have long-term expression from your viral vector you will not have to worry about a second administration. viral gene therapy to the brain is a promising platform.

non-viral gene therapy sucks (i assume you are talking about plasmid DNA).