What are the two types of ATP synthesis and how do they differ?

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Indirect ATP formation refers to oxidative phosphorylation, which occurs in the electron transport chain where a proton gradient (proton motive force) is utilized to attach inorganic phosphate to ADP. This process contrasts with direct ATP synthesis, known as substrate-level phosphorylation, where a phosphate group is directly transferred from a substrate molecule to ADP. The discussion highlights that in substrate-level phosphorylation, the phosphate donor can vary, as seen in the conversion of succinyl CoA to succinic acid in the Krebs cycle. Overall, the key distinction lies in the mechanisms of ATP generation: direct synthesis involves direct phosphate transfer, while indirect synthesis relies on a gradient-driven process.
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I came across a term "indirect atp formation"I am not sure what it is ?
What is the difference between direct and indirect atp synthesis?I think substrate level phosphorylation (where a molecule directly donates a phosphate to ADP) is direct atp synthesis.Indirect atp synthesis is oxidative phosphorylation (in the electron transport chain; using the H+ gradient to attach inorganic phosphate to ADP).
Right?
 
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gracy said:
think substrate level phosphorylation (where a molecule directly donates a phosphate to ADP) is direct atp synthesis
The phosphate need not come from the molecule, the energy liberated during the conversion might just help in adding that Pi to ADP/GDP, eg:succinyl CoA to succinic acid in kreb's cycle.
gracy said:
oxidative phosphorylation (in the electron transport chain; using the H+ gradient to attach inorganic phosphate to ADP).
Yes, by PMF(proton motive force) and oxysomes(FoF1 particle)
 

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