What does it mean by PC in this article?

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SUMMARY

The term "PC" in the discussed article refers to "pseudo-center," which is a key concept in the PCASSO (Protein C-Alpha Secondary Structure Output) application. PCASSO utilizes a method similar to SABA, where the coordinates of the ith Cα atom are shifted to its pseudo-center position, defined as the center-of-geometry between Cα(i) and Cα(i+1). This approach enhances the accuracy of assigning secondary structure elements (SSEs) by using optimized PC-dependent geometric criteria. The minimum cut-off distance for this algorithm is established at 6, although the maximum cut-off distance remains unspecified and is likely an accuracy function rather than a fixed value.

PREREQUISITES
  • Understanding of protein structure and secondary structure elements (SSEs)
  • Familiarity with the PCASSO algorithm and its application in bioinformatics
  • Knowledge of geometric criteria in protein modeling
  • Experience with computational biology tools such as SABA
NEXT STEPS
  • Research the implementation details of the PCASSO algorithm in protein structure analysis
  • Explore the geometric criteria used in SABA and PCASSO for assigning SSEs
  • Investigate the implications of cut-off distances in protein modeling algorithms
  • Learn about alternative methods for secondary structure assignment in bioinformatics
USEFUL FOR

Bioinformaticians, computational biologists, and researchers involved in protein structure analysis and secondary structure prediction will benefit from this discussion.

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https://pubmed.ncbi.nlm.nih.gov/24995959/

What does it mean by PC in this article?

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From the paper, PC is pseudo-center, @user366312.

Specifically, they are referring to the application: "SABA uses a similar approach to P-SEA but instead of directly computing the Cα coordinates SABA shifts the coordinates of the ith Cα atom to its pseudo-center (PC) position (defined as the center-of-geometry between Cα(i) and Cα(i+1)) and then assigns SSEs based on an optimized set of PC-dependent geometric criteria. This is thought to better represent the location of the backbone N-H/C=O atoms involved in secondary structure formation."

The application in the paper, PCASSO (Protein C-Alpha Secondary Structure Output), is an alternative approach to SABA (and others) that claims to be fast and efficient in assigning protein SSEs that only requires Cα atoms as input.
 
I see that the minimum cut-off distance is 6.
What is the maximum cut-off distance?
 
user366312 said:
I see that the minimum cut-off distance is 6.
What is the maximum cut-off distance?
Are you referring to the kth residue as 'distance'? If so, can't see a maximum, it is probably an accuracy function rather than a specific value.
 
What does it actually mean by a "cut-off" in this PCASSO algorithm?
 
user366312 said:
What does it actually mean by a "cut-off" in this PCASSO algorithm?
Can you note the section of the paper where you're reading this, @user366312, because I am not sure what aspect of PCASSO you are referring to?
 

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