E=mc² is a fundamental equation in physics that expresses the equivalence of mass and energy, stating that energy equals mass multiplied by the speed of light squared. It is primarily used in nuclear reactions to illustrate how mass can be converted into energy and vice versa. An example provided shows that converting the mass of helium in a balloon into energy could yield approximately 180 terajoules, equivalent to the energy released by 43 kilotonnes of TNT. The equation also implies that energy can create mass, though this process requires an immense amount of energy. Understanding E=mc² is crucial for fields related to special relativity and nuclear physics.