Newton's laws of motion are only valid in inertial frames because they do not account for fictitious forces present in non-inertial frames. In non-inertial frames, forces like the Coriolis and centrifugal forces must be introduced to apply Newton's laws correctly. These fictitious forces arise due to acceleration and are essential for maintaining the consistency of Newtonian mechanics in rotating or accelerating reference frames. Thus, while Newton's laws can be adapted for non-inertial frames, they require the inclusion of these additional forces. Understanding this distinction is crucial for accurately applying Newton's laws in various contexts.