Medical Selectively raising or lowering the temperature of certain organs

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The discussion centers around the concept of manipulating the temperature of a solitary organ for medical purposes. Controlled temperature changes are recognized as safe and beneficial for specific conditions, suggesting the potential for localized temperature adjustments to treat particular organs without affecting the entire body. This method, while considered extreme, raises questions about its plausibility and possible applications. One established technique mentioned is localized hyperthermia therapy, which is commonly used to treat solid tumors by applying heat directly to the tumor site, enhancing treatment efficacy while minimizing systemic risks.
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I was thinking the other day on whether there are any medical procedures that involve raising or lowering the temperature of a solitary organ. I know controlled temperature changes are mostly safe and useful for certain conditions. It seems that this could be useful for doing it to one particular organ where doing it to the entire body could be otherwise dangerous. This seems to be an extreme measure to take but is it plausible? Is there anything that this could possibly treat?
 
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localized hyperthermia therapy is a common technique for treating solid tumours
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) he structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom

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