Ideal locations for a manned mission to Mars include lava tubes and polar ice caps, which offer protection from radiation and potential water sources. The discussion highlights the importance of survival and scientific exploration, particularly in searching for signs of life. Concerns about the feasibility and cost of such missions are raised, with many suggesting that robotic missions may be more effective and less risky. The Valles Marineris is also mentioned as a potential site for a permanent colony due to its dense atmosphere, although water sourcing remains a challenge. Overall, while there are compelling arguments for manned missions, significant technological and financial hurdles must be addressed.