The discussion centers on the prevention of STDs, particularly HPV, HSV, and HIV. It highlights that while antiviral drugs are effective for treating viral infections, they do not prevent transmission and can have significant side effects. Safer alternatives for reducing STD risk include the use of condoms and other barrier methods, which are noted to be highly effective. A more reliable strategy is to require STD screening for all sexual partners before engaging in sexual activity, ensuring that both parties are tested and clear of infections. The only guaranteed method to avoid STDs is complete abstinence from sexual contact, though this is not a common choice for many individuals.