Fermat's Little Theorem (FLT) is efficient for large numbers, particularly in modular exponentiation and primality testing, such as the Fermat primality test. In contrast, Wilson's Theorem is considered less useful, with limited applications primarily in analytic contexts. While FLT has practical uses in number theory, Wilson's Theorem does not significantly contribute to finding primes. The discussion highlights the efficiency of FLT compared to Wilson's Theorem in real-life applications. Overall, FLT is a valuable tool in number theory, while Wilson's Theorem has restricted relevance.