The discussion centers on calculating the total number of atoms in a bottle of nail polish remover containing approximately 2.5 moles of ethyl acetate (C4H8O2). Each molecule of ethyl acetate consists of 14 atoms, derived from 4 carbon, 8 hydrogen, and 2 oxygen atoms. Participants clarify that to find the total number of atoms, one must multiply the number of atoms per molecule by the total number of molecules in the bottle, which is calculated using Avogadro's number. The correct calculation leads to a total of approximately 2.1 x 10^25 atoms in the bottle. The conversation emphasizes the importance of accurate calculations and understanding the mole concept in chemistry.