Medical "Berlin Patient" Cured of HIV? Investigating a Miraculous Case

  • Thread starter Thread starter aquitaine
  • Start date Start date
AI Thread Summary
The discussion centers on the case of Timothy Ray Brown, known as the "Berlin patient," who was functionally cured of HIV after receiving a bone marrow stem cell transplant from a donor with a rare genetic immunity to the virus. This case has generated significant excitement in the HIV advocacy community, as it represents a potential breakthrough in treatment. However, skepticism exists regarding the practicality of this approach as a widespread solution to the HIV epidemic. Critics highlight the challenges, including the need for a compatible donor, the high costs associated with bone marrow transplants, and the lifelong requirement for immunosuppressants, which can lead to increased health risks. Overall, while the case is seen as a remarkable individual success, it raises questions about its viability as a general cure for HIV.
aquitaine
Messages
30
Reaction score
9
HIV "cure"?

http://news.yahoo.com/s/yblog_thelookout/20110603/us_yblog_thelookout/first-man-functionally-cured-of-hiv

Since HIV was discovered 30 years ago this week, 30 million people have died from the disease, and it continues to spread at the rate of 7,000 people per day globally, the UN says.

There's not much good news when it comes to this devastating virus. But that is perhaps why the story of the man scientists call the "Berlin patient" is so remarkable and has generated so much excitement among the HIV advocacy community.

Timothy Ray Brown suffered from both leukemia and HIV when he received a bone marrow stem cell transplant in Berlin, Germany in 2007. The transplant came from a man who was immune to HIV, which scientists say about 1 percent of Caucasians are. (According to San Francisco's CBS affiliate, the trait may be passed down from ancestors who became immune to the plague centuries ago. This Wired story says it was more likely passed down from people who became immune to a smallpox-like disease.)

What happened next has stunned the dozens of scientists who are closely monitoring Brown: His HIV went away.

"He has no replicating virus and he isn't taking any medication. And he will now probably never have any problems with HIV," his doctor Gero Huetter told Reuters. Brown now lives in the Bay Area, and suffers from some mild neurological difficulties after the operation. "It makes me very happy," he says of the incredible cure.
I'd like to know if it is the real deal or overhyped?
 
Last edited by a moderator:
Biology news on Phys.org


Borek said:
Old news. Please read the last paragraph here: http://en.wikipedia.org/wiki/AIDS#Research_directions

But it doesn't look to me like a viable way of dealing with the disease. Finding a donor for each AIDS patient?

Not to mention you'll be on an equally expensive regime of immunosuppressants the rest of your life and more prone to infectious disease.

Its not a fix at all, its simply trading off one evil for another (not even necessarily the lesser one in some circumstance, ie; graft v host disease).
 


I didn't even know this was possible. Even if it was as you said "trading one evil in for another" it's still a big breakthrough.
 


sadsoul81 said:
I didn't even know this was possible. Even if it was as you said "trading one evil in for another" it's still a big breakthrough.

I'm not so sure it is to be honest. Bone marrow transplants are expensive, require trained physicians, require a close match and leave the patient on immunosuppressants for the rest of their life thus increasing their chance of getting ill and thanks to the transplant are always at the risk of rejection.

In terms of solving the HIV endemic I don't see this as a viable route to a cure. It's interesting but doesn't really solve anything.
 
Thread 'Did they discover another descendant of homo erectus?'
The study provides critical new insights into the African Humid Period, a time between 14,500 and 5,000 years ago when the Sahara desert was a green savanna, rich in water bodies that facilitated human habitation and the spread of pastoralism. Later aridification turned this region into the world's largest desert. Due to the extreme aridity of the region today, DNA preservation is poor, making this pioneering ancient DNA study all the more significant. Genomic analyses reveal that the...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom
https://www.nhs.uk/mental-health/conditions/body-dysmorphia/ Most people have some mild apprehension about their body, such as one thinks their nose is too big, hair too straight or curvy. At the extreme, cases such as this, are difficult to completely understand. https://www.msn.com/en-ca/health/other/why-would-someone-want-to-amputate-healthy-limbs/ar-AA1MrQK7?ocid=msedgntp&cvid=68ce4014b1fe4953b0b4bd22ef471ab9&ei=78 they feel like they're an amputee in the body of a regular person "For...

Similar threads

Replies
8
Views
5K
Replies
1
Views
2K
Replies
4
Views
5K
Replies
21
Views
3K
Replies
3
Views
3K
Replies
4
Views
5K
Back
Top