To calculate the number of ways to arrange 6 letters from the 7 letters in "SETTEES," the result is 210. The process involves considering different cases based on the repetition of letters, such as having three identical letters of one kind, two of another, and one of a third. Using the multinomial theorem simplifies the calculation by allowing for the counting of choices at each stage and then dividing out equivalent arrangements. Specifically, arrangements of letters with duplicates require accounting for indistinguishable letters to avoid overcounting. Ultimately, the method involves multiplying the permutations of distinct arrangements and dividing by the factorial of the counts of identical letters.