To calculate the RMS value for a wave with unequal peak amplitudes, the standard formula of peak positive amplitude divided by root 2 does not apply directly. Instead, it is suggested to average the amplitudes, effectively shifting the reference point to equalize positive and negative amplitudes. The RMS voltage can be calculated using the formula √(V1² + V0²/2), where V1 represents the constant offset voltage and V0 is the sinusoidal amplitude. The discussion highlights the importance of understanding the relationship between the amplitudes to achieve an accurate RMS calculation. Clarifications and detailed calculations can be provided upon request.