Pressure differentials caused by altitude changes during flights can lead to temporary pain and may create conditions conducive to lasting infections, particularly in the inner ear and sinuses. Fluid build-up in the inner ear increases the risk of infection, as experienced by individuals who have suffered from sinus infections following flights or deep dives. The change in pressure can force mucus, potentially containing bacteria, into the inner ear via the Eustachian tube, leading to painful infections. This highlights the importance of understanding the risks associated with flying and altitude changes on ear and sinus health.