Graphical Windows applications can be developed without using WinAPI libraries by utilizing multi-platform GUI libraries like Gtk and Qt. Qt is often recommended for its performance and customizable UI design, as it employs its own paint engine, distinguishing it from other libraries that typically wrap around Win32 APIs. While WinAPI is generally considered to offer the best performance on Windows, alternatives like Java's Swing and SWT provide programmer-friendly options without relying on Windows-specific APIs. Additionally, game engine GUIs such as Unreal Engine's interface or CrazyEddy's GUI (CEGUI) can also be explored for application development. Overall, the choice between these libraries depends on the desired balance between customization, performance, and ease of use.