The Ricci Tensor (##R_{\mu\nu}##) is a tensor that represents curvature. It was invented by mathematicians, and satisfies a number of useful properties. The tensor ##R_{\mu\nu}-\frac{1}{2}Rg_{\mu\nu}## is called the trace reverse of the Ricci Tensor, and satisfies the following very important property: It's components represent the same geometric object all over spacetime. It's like having a vector field whose vectors are parallel everywhere.
The Stress Energy Tensor (##T_{\mu\nu}##) is a tensor whose components represent energy and momentum in spacetime. Roughly speaking,
##T_{00}## = Mass/Energy
##T_{01}, T_{02}, T_{03}## = Momentum
##T_{11}, T_{12}, T_{13},T_{22},T_{23},T_{33}## = Stress
(The Stress Energy Tensor is symmetric, which means that ##T_{\mu\nu} = T_{\nu\mu}##, and so ##T_{10}## is the same as ##T_{01}##.)
The generalization of conservation of Energy and Momentum into General Relativity is the fact that this tensor is also geometrically invariant, just like the Ricci Tensor. Einstein proved that this means we can say:
$$R_{\mu\nu}-\frac{1}{2}Rg_{\mu\nu} = kT_{\mu\nu}$$
where ##k## is some constant. If you solve these equations for the case of a weak gravitation field, you retain the Newtonian equations of gravity if and only if ##k=\frac{8\pi G}{c^4}##. However, physicists can perform special tricks that get rid of the ##G## and the ##c##, so long as they transform all measured quantities into new units before plugging them into equations. This means that the only part of the constant that is fundamental to General Relativity is ##8\pi##, the fact that the constant is (roughly) ##10^{-44}## and not the fundamental ##8\pi## is a result of poorly chosen units for measuring distance and mass.
So, to answer your question directly, ##10^{-44}## doesn't have much real significance in relativity, it simply pops up because we chose to work with unnatural units. ##8\pi## has the real significance, and there is probably no simple physical reason that ##8\pi## shows up in our equations, though I would encourage someone with more knowledge on the topic to chime in if they have a purely physical explanation.