To effectively cancel out power supply noise while measuring the noise of a 600 MΩ resistor, circuit design must consider the inherent limitations of power supplies, as complete noise cancellation is impossible. Using a high-voltage capacitor in place of a resistor may reduce noise, but achieving balance in the circuit remains challenging. The bandwidth of interest is critical; for example, a power supply that allows mains noise may be acceptable for certain frequency ranges but problematic for others. Additionally, thermal noise from the resistor can significantly impact measurements, necessitating bandwidth restrictions to mitigate this effect. Overall, careful consideration of circuit configuration and measurement parameters is essential for accurate noise assessment.