atyy said:
But if [...] quantum theory applies to everything, then there should be a wave function of the universe, and it should make physical sense without many-worlds or Bohmian mechanics.
There must be a state of the universe, but not necessarily a wave function -- it could be a mixed state. It does indeed make physical sense:
According to my http://arnold-neumaier.at/physfaq/cei/ , we need a Hilbert space carrying a representation of the standard model plus some (not yet decided) form of gravity, unitary dynamics for operators, density operators for Heisenberg states, the definition of ##\langle A\rangle:=\mbox{tr}~\rho A## as mathematical framework, and for its interpretation a single rule:
Upon measuring a Hermitian operator ##A##, the measured result will be approximately ##\bar A=\langle A\rangle##, with an uncertainty
at least of the order of ##\sigma_A=\sqrt{\langle (A-\bar A)^2\rangle}##. If the measurement can be sufficiently often repeated (on an object with the same or sufficiently similar state) then ##\sigma_A## will be a lower bound on the standard deviation of the measurement results.
Everyone doing quantum mechanics uses these rules (even those adhering to the shut-up-and-calculate mode of working), and they apply universally. No probabilistic interpretation beyond that is needed, so it applies also to the single universe we live in. Everything deduced in quantum field theory about macroscopic properties follows, and one has a completely self-consistent setting. The transition to classicality is automatic and needs no deep investigations - the classical situation is simply the limit of a huge number of particles. Whereas on the microscopic level, uncertainties of single events are large, so that state determination must be based by the statistics of multiple events with a similar preparation.
We cannot expect to measure all the observables of the whole universe, and perhaps never determine its precise state. But measuring all observables or finding its exact state is already out of the question for a small quantum system such as a shaken bottle of water. What matters for a successful physics of the universe is only that we can model (and then predict) the observables that are accessible to measurement.