Could Synthetic Biology Create Alternative Forms of Life?

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The discussion explores the potential for synthetic biology to create life forms with alternative biochemistries, such as boron-based life or organisms using solvents like ammonia or sulfuric acid instead of water. It acknowledges the possibility of alternative biochemistries arising naturally, with ammonia being considered more likely than sulfuric acid. While there are currently no established equations to predict the prevalence of such life forms, factors like the stability of chemicals under various temperature and pressure conditions are crucial. The conversation emphasizes that alternative biochemistries remain largely theoretical, with existing knowledge primarily based on Earth's biochemistry. The role of water in facilitating metabolic processes through hydrogen bonding is highlighted, suggesting that any non-carbon-based life would need a compatible solvent to support similar processes. The discussion encourages further exploration of relevant resources, including Wikipedia articles on alternative biochemistry.
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Is it possible to use synthetic biology to create new kinds of life with alternative biologies such as a boron based lifeform or a solvent other than water such as ammonia or sulfuric acid? Alternatively, what is the likelihood of alternative biochemistries arising naturally as compared to life as it has manifested on earth? Is there some sort way of comparing the relative likelihoods of various forms of life arising (similar to the drake equation) based on the prevalence of the various atoms on which they are based?
 
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I think other threads cover creating synthetic biochemisteries. As for alternative biochemisties arising naturally I'd say it's possible. Especially for ammonia or hydrofluoric acid based life. Ammonia being the more likely of those two. Not sure about sulfuric acid though. Currently there are not equations to calculate how common this sort of life may be, but I'm sure one could be found. There are lots of considerations than just how abundant a chemical is. Like at what temperature and pressure ranges are those chemicals stable and in the desired state. The lower the energy state the more time it takes for time to develop. Alternative biochemisteries are just a thought experiment at this point, at least beyond the wide range of biochemisteries that are known on Earth already.
 
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Thank you very much @Ittiz, hopefully others who see this might provide any relevant links that they're aware of
 
There really isn't anything to say that it is not possible. It would seem that such an element would likely fall within the middle of the periodic table (like carbon is), as such elements have great flexibility towards donating, accepting or sharing electrons to achieve a very wide variety of molecules that would be useful for life.

Water works so well as the 'lubrication' of carbon based life because hydrogen bonds are easily broken and then re-established. This allows for metabolic processes, where various chemicals are created in a chain like fashion (one gets converted into another and that product subsequently gets converted into something else, etc). Something other than carbon would require an analog to water that would be compatible with it to facilitate resulting metabolic processes.
 
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