Current discussions on the most efficient catalyst reactions highlight the complexity of measuring catalyst efficiency, which can be assessed through turnover frequency (TOF) and turnover number (TON). TOF indicates how many catalytic processes occur per unit time, while TON reflects how many times a catalyst can operate before degradation. Notable metal-based catalysts include ruthenium, achieving TONs in the millions, and rhodium, with TONs in the hundreds of thousands. TOF values for rhodium and gold catalysts can reach up to 400 TO/hr. However, enzymes are considered the most efficient catalysts, with theoretical TONs that far exceed those of metal catalysts due to their stability and adaptability in biological conditions. Enzymatic TOFs can be exceptionally high, with some reported at 4.2 TO/sec, equating to over 15,000 TO/hr. The discussion suggests that while metal catalysts are significant, enzymes may represent the pinnacle of catalytic efficiency, although further exploration in biological literature is needed for comprehensive insights.