Delete Temp Files? Cleaning AppData/Local

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Files with the prefix DIO and MSG in the appdata/local/temp directory are temporary files that can accumulate and take up significant disk space. These files are typically safe to delete, as they are often remnants of applications that can be regenerated if needed. It is generally accepted that the contents of the Temp folder are expendable, and deleting them will not harm system functionality. Regularly clearing out the Temp folder can help maintain system performance and free up storage space.
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More cleaning.

So within my appdata/local/temp I found a loooot of files starting with DIO(number)and sometimes (A,B,C,D or a combo of those).tmp

For example
DIO82.tmp
DIO82AB.tmp
DIO235C.tmp

They are taking up so much space, and google kinda makes it sound like they're even remnants of malware.

Can I delete these? Thanks.

EDIT: There are also similar files with MSG(numbers and letters).tmp
Can I delete those? :P

MOAR EDIT: Can't I just delete EVERYTHING in my Temp?
 
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Generally anything in a Temp folder is expendable and if it is needed to run a program, that program will generate new one.
 

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