Drilling a 3/8" hole in a steel tube for a go-kart frame raises safety concerns due to potential weakening, especially if the hole is near the center of the frame where stress is highest. While a small hole can increase local stresses significantly, the overall safety margin of the tube is considered adequate for typical loads. Some participants suggest using a smaller hole or welding it back up after feeding the cables to minimize risk. The discussion highlights the importance of designing for worst-case scenarios, particularly regarding crash impacts, although sustained cornering forces are noted to be less severe. Ultimately, caution is advised, but the tube's construction may allow for safe modifications.