You are almost there...but...I suspect hanging a vacuum gage on an engine in the dyno room is not telling the whole story.Leaving aside air resistance for the moment, the answer is the lowest RPM in the highest gear.
As for the specific question you posed, air resistance also comes into play Big time. For any vehicle, the higher the speed, the greater the air resistance. But some vehicles have far less drag than others, and so the effect of air resistance for those vehicles is less than it is for others.
Waddel Wilson ( famous Nascar Crew chief) one said “ ifin you're moving , you're moving air” or something like that
Basic mathematical formula for the amount of power it takes to move your car at certain speeds.
Driving load = av + bv2 + cv3
The "av + bv2" part has to do with how much power it takes to overcome the resistance due parasitic drag, internal friction of the engine, like ring drag, bearing rotating friction etc.. plus tire
resistance, disc brake drag, drive shaft friction, transaxle gear friction etc..all to get the car rolling at a given speed.
The "cv3" part has to do mostly with power required to overcome wind resistance (or "drag") while driving.
When doing this formula, your replace a, b, and c with the speed you're driving at. Let's assume this speed is in miles per hour (mph).
The biggie is the "power of 3" aspect of this formula..It means that wind drag will be the largest force your car will have to fight. And believe me..it is HUGE.
Ifin we are going 60 mph:
Driving load = 60 +3600 + 216,000 = 219660 units
These "units" could be anything - horsepower, Newtons, Joules ,cans of beer??
Based on this formula, the amount of power required to drive at 60 mph is 219660 units. Based on the same formula, the amount of power required to drive at 65 mph is 278915 units. The difference is 59255!
This is an increase of about 27% more effort your car has to make just to drive 5 mph faster
not being a degreed professional engineer...i can not explain it more but recommend you check out this link which is very in detail reagrding the formula...
http://autopedia.com/stuttgart-west/Physics/StuttPhysics06.html